PYROLURIA: PYROLE DISORDER (PD)
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PYROLURIA: PYROLE DISORDER (PD)

Pyrole Disorder (PD) is a disease leading to the inability to regulate the stress response-> severe stress & anxiety states. Pyroluria is accumulation of pyrole molecules, a by-product of red blood cells synthesis, in the urine as a marker of the disease process. The disease can be genetic or epigenic (acquired genetic problem). Oxidative stress & inflammatory states trigger or exacerbate PD. Pyrole accumulation leads to a double B6/ pyridoxine & zinc deficiency-> both depression & anxiety!  

  • The conversion of B6 to its active form called P5P is needed for dopamine & GABA production in the brain, and many other biochemical activities.

  • Zinc facilitates the conversion of B6 into P5P. A zinc deficiency indirectly à GABA & dopamine deficiency, and slows clearance of epinephrine. Zinc activates the NMD receptor to affect brain function, and fortify the blood brain barrier against oxidative stress & inflammation. Zinc also supports immune function and hormone balance. Zinc deficiency correlates with “bad temper”,
 
Pyroluria is exacerbated by and often seen with these in *Alcoholism & substance abuse, Autism/ASD, anxiety disorders, behavioral disorders & criminal behavior, depression, Tourettes,  Down syndrome, epilepsy, learning disability, mood swings & neurosis, psychosis & schizophrenia Opposition Defiant Disorder,  PTDS,   Alzheimer’s. *According to one alcoholism treatment center, 1/3 to 1/2 of alcoholics treated had PD. 

Sign & Symptom Map of PD:
  • *Extreme mood swings #1  
  • *Poor stress control  
  • *Irritability & temper
  • *Severe depression & pessimism
  • *Severe inner tension or anxiety
  • *Histrionic behavior
  • *Sensitivity to bright lights or loud noises
  • *Affinity for spicy foods
  • *Spleen/LUQ pain
  • *Poor growth & muscle development until after age 16- Delayed Puberty
  • History of reading disorders
  • Underachievement despite intelligence
  • Abnormal/absent menses
  • Poor shorterm memory
  • Morning nausea -> tendency to skip breakfast
  • Tendency to stay up late
  • Poor or no dream recall
  • Frequent infections & poor wound healing
  • Joint pain
  • White spot on nails
  • Pale skin & inability to tan
  • Delicate facial features
  • Acne or very oily skin 
  • Coarse eyebrows
  • Fruity Body order or breath
  • Premature graying
  • Stretch marks
  • Psoriasis
  • Abnormal fat distribution
  • Terrible 2’s
  • Social withdrawal
  • Fear, worry, obsessions & negative thoughts
  • Prior diagnosis of ADHA
  • Learning disabilities
  • Temper Dysregulaton Disorder, Oppositional Defiant Disorder, Bipolar, *Schizophrenia
  • Autoimmune disorders
  • Highly abnormal sleep cycle study
  • Abnormal EKG

Diagnostic Lab Tests for PD:
Two people can test positive for PD. However, they can differ in their expression & symptom severity. Meaning one may have severe signs while the other may have no symptoms at any particular time. Stress, oxidative stress & inflammation are significant triggers (from even the common cold & flus to cancer). And a person may only test positive when under a psycho emotional or physical stressor. Pyrole elevation can in fact be used as an inflammatory marker, and is seen in *5% of “healthy ” controls.
 
  • Markers of Severe Oxidative Stress (can trigger psychosis in anyone already susceptible (e.g. low glutathione)
  • Elevated urine kryptopyroles ->  mauve colored-urine.

Differential Diagnosis:
There are many more differential diagnosis & nutrient deficiencies leading to similar/ same signs & symptoms as PD:

  • Fattyacidimbalance -> depression, ADHD, schizophrenia, bipolar, dementia.
  • Seizure medication (e.g. Depakote) can cause severe zinc deficiency.
  • Stress can trigger epigenic PD - these genes can be turned off
  • 4 Bipolar Biochemical Classifications:


1. Under-methyltionà depression, eating disorders, OCD, perfectionism, *histamine elevation.

2. Over-methyation (methyl folate deficiency) à anxiety/ anxious depression, panic, sensitivity to pesticides, chemicals & foods, and * histamine depression.

3. CopperOverloadà low dopamine, increased epinephrineà paranoid schizophrenia, ADHD, bipolar, postpartumdepression, violent behavior.

4. PyroleDisorder
 
*Histamine is a marker of all the methylation processes in the body combined.
 
TREATMENT
PD may begin to respond to continued controlled, individualized TherapeuticDosing (prescribed) of key micronutrients within 2-4 weeks if mild, and 1-3 months if severe. Then improving gradually over 3 to 12 months:
 

  • B6 (P5P) & Zinc + supportive nutrients to manage oxidative stress & inflammation.
  • Stress Management. Stressors can trigger epigenic PD - these genes can be turned off.
  • AVOID omega 3 fatty acids (both plant & fish oil sources), because Pyrolurics have a problem processing them along the arachidonic acid pathwayà possible exacerbation of signs & symptoms.

Testing & Consultation: Dr. Albert Mensah MD at www.pyroluriatesting.com. And him on:



  • Nutrient Powerby Dr. William Walsh on the benefits & harms of nutracueticals. 


















 

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