Pyrole Disorder (PD) is a disease
leading to the inability to regulate the stress response-> severe stress & anxiety states. Pyroluria is accumulation of pyrole molecules, a by-product of red blood cells synthesis, in the urine as a
marker of the disease process. The disease can be genetic or epigenic (acquired
genetic problem). Oxidative stress & inflammatory states trigger or
exacerbate PD. Pyrole accumulation leads to a double B6/ pyridoxine & zinc
deficiency-> both depression & anxiety!
- The conversion of B6 to its active
form called P5P is needed for
dopamine & GABA production in the brain, and many other biochemical
- Zinc facilitates the
conversion of B6 into P5P. A zinc deficiency indirectly à GABA & dopamine deficiency, and slows clearance
of epinephrine. Zinc activates the NMD receptor to affect brain function, and
fortify the blood brain barrier against oxidative stress & inflammation.
Zinc also supports immune function and hormone balance. Zinc deficiency
correlates with “bad temper”,
Pyroluria is exacerbated by and often seen with these in *Alcoholism & substance abuse, Autism/ASD, anxiety disorders, behavioral disorders & criminal behavior, depression, Tourettes, Down syndrome, epilepsy, learning disability, mood swings & neurosis, psychosis & schizophrenia
Opposition Defiant Disorder, PTDS, Alzheimer’s. *According to one alcoholism treatment center, 1/3 to
1/2 of alcoholics treated had PD.
Symptom Map of PD:
mood swings #1
depression & pessimism
inner tension or anxiety
to bright lights or loud noises
for spicy foods
growth & muscle development until after age 16- Delayed Puberty
- History of
nausea -> tendency to skip breakfast
to stay up late
- Poor or no
infections & poor wound healing
- Joint pain
- White spot
- Pale skin
& inability to tan
- Acne or
very oily skin
- Coarse eyebrows
Body order or breath
- Fear, worry,
obsessions & negative thoughts
diagnosis of ADHA
- Learning disabilities
- Temper Dysregulaton Disorder, Oppositional
Defiant Disorder, Bipolar, *Schizophrenia
abnormal sleep cycle study
Lab Tests for PD:
Two people can test positive for PD.
However, they can differ in their expression & symptom severity. Meaning
one may have severe signs while the other may have no symptoms at any
particular time. Stress, oxidative stress & inflammation are significant
triggers (from even the common cold & flus to cancer). And a person may
only test positive when under a psycho emotional or physical stressor. Pyrole
elevation can in fact be used as an inflammatory marker, and is seen in *5% of “healthy ” controls.
- Markers of
Severe Oxidative Stress (can trigger
psychosis in anyone already susceptible (e.g. low glutathione)
urine kryptopyroles -> mauve
There are many more differential diagnosis & nutrient deficiencies
leading to similar/ same signs & symptoms as PD:
- Fattyacidimbalance -> depression, ADHD, schizophrenia, bipolar, dementia.
- Seizure medication (e.g. Depakote) can cause
severe zinc deficiency.
- Stress can trigger epigenic PD - these genes can be turned off
- 4 Bipolar Biochemical Classifications:
depression, eating disorders, OCD, perfectionism, *histamine elevation.
2. Over-methyation (methyl folate deficiency) à anxiety/ anxious depression, panic, sensitivity to
pesticides, chemicals & foods, and * histamine depression.
3. CopperOverloadà low
dopamine, increased epinephrineà paranoid
schizophrenia, ADHD, bipolar, postpartumdepression, violent behavior.
is a marker of all the methylation processes in the body combined.
PD may begin to respond to continued
controlled, individualized TherapeuticDosing (prescribed) of key micronutrients within 2-4 weeks if mild, and 1-3
months if severe. Then improving gradually over 3 to 12 months:
- B6 (P5P) & Zinc + supportive nutrients to manage oxidative stress &
- Stress Management. Stressors can trigger
epigenic PD - these genes can be turned
- AVOID omega 3 fatty acids (both plant
& fish oil sources), because Pyrolurics have a problem processing them
along the arachidonic acid pathwayà possible
exacerbation of signs & symptoms.
- Nutrient Powerby Dr. William Walsh on the benefits & harms of nutracueticals.